Implementation Science Extends Multidisciplinary Education on VTE Prophylaxis at World-Class Children’s Hospital

Let’s continue yesterday's thread with venous thromboembolism (VTE) education in a new patient population: children. In this quality improvement article, Raffini et al point out that while risks of VTE are far lower in children than in adults, children still need clinicians to maintain an appropriate level of suspicion and take action on VTE risk with prophylaxis.

What a nice way to phrase a practice gap and the need to narrow that gap: “VTE prophylaxis for patients at risk is often overlooked in pediatric health care institutions, which provides an opportunity to improve patient care.” Even at the world-class Children’s Hospital of Philadelphia (CHOP) at the University of Pennsylvania, children and adolescents were not receiving an appropriate level of risk assessment and prophylaxis, leading researchers to undertake this four-year quality improvement study.

CME/CEhp initiatives often do not extend into local facilities, but this study used reinforcing methods of implementation science to communicate and support the desired behaviors and tasks. These extended “multidisciplinary educational forums” into patient-care settings. Here’s a summary of the intervention’s rollout of CHOP’s locally established guidelines to “encourage timely initiation of thromboprophylaxis." These interventions included 1) VTE risk assessment in the nursing admission intake forms; 2) a VTE-prophylaxis order set implemented into the computerized ordering system; 3) ICU nurses assessing VTE risk and preventive practice daily during team rounds; 4) trials of various pneumatic compression devices with appropriate sizing for children; 5) acquisition of more compression devices with storage near high-risk areas; and 6) development of a protocol for perioperative nurses to initiate pneumatic compression before surgery for certain patients, later expanded to all inpatient settings.

So was extension of multidisciplinary education into care settings, using methods of implementation science, effective? YES. The study’s primary outcome measure was “compliance with thromboprophylaxis guidelines in patients at risk for VTE.” Clinically meaningful improvements were seen: “Over the 4-year study period, the observed rate of VTE prophylaxis in patients at risk increased from a baseline of 22% to an average rate of 82%, and there were intermittent improvements up to 100%.” Implementation science methods, when added to multidisciplinary clinical education, quadrupled or even quintupled guidelines-based care in an underserved population.    

There’s also a nice feature to point out to those watching IRB “requirements” that peer-reviewed journals increasingly expect of performance-change initiatives: “This project was a quality-improvement activity and exempt from review from the institutional review board at the Children's Hospital of Philadelphia.” The QI initiative was not seen as human subjects research (HSR).

Reference cited: Raffini L, Trimarchi T, Beliveau J, Davis D. Thromboprophylaxis in a pediatric hospital: a patient-safety and quality-improvement initiative. Pediatrics. 2011;127(5):e1326-32. PMID: 21464186.
See also the ACCP and ICSI guidelines linked from the September 7, 2015 post (http://fullcirclece.blogspot.com/2015/09/pharmacy-education-for-hospital.html)
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/21464186
Free full text (Pediatrics final version): http://pediatrics.aappublications.org/content/127/5/e1326.full.pdf+html
MeSH *Major* terms: Anticoagulants/administration & dosage*; Guideline Adherence*; Patient Selection*; Primary Prevention/organization & administration*; Venous Thromboembolism/prevention & control*
(And for those of you who love MeSH and UMLS, many quality-improvement and program change-related MeSH terms were assigned by NLM but not starred as “major” terms.) 

Pharmacy Education for Hospital Clinicians on VTE Prophylaxis Changed Performance, Bringing Guideline-Adherent Care To Most Patients

Earlier today, I wrote of interprofessional clinical education regarding team communication during cardiac surgery. Now I continue the theme of nonphysician education by highlighting contributions of pharmacy education to patient care, and one that particularly relates to (post)surgical care. While this month’s Back-to-School campaign (illustrating published educational outcomes) mainly features recent articles, this 2005 study by Dobesh and Stacy in the Journalof Managed Care Pharmacy (free full text available) is a worthy read for its contributions to quality care research from the pharmacy perspective and scope of practice.

Venous thromboembolism (VTE and/or DVT, PE) is a great concern among surgeons and other physicians. In fact, the VTE evidence-basedguideline by the Institute for Clinical Systems Improvement (ICSI; Jobin et al 2012) names 10 stakeholder groups—including physicians and pharmacists—as “intended users.” The current article used the 2004 American College of Chest Physicians (ACCP) recommendations. Effectively preventing VTE can dictate the chances of successful outcomes and reduce patient readmission rates for many conditions. Because of the challenges of selecting the optimal anticoagulant agent and dosage for individual patients, pharmacists can clearly collaborate with physicians in making decisions about VTE prophylaxis. The 2012 guideline considered pharmacological thromboprophylaxis with unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), fondaparinux, warfarin, aspirin, apixaban, dabigatran, and rivaroxaban—enough therapeutic options to suggest the need for consultation between physicians and pharmacists.  

The pharmacy intervention for nurses, pharmacists, and physicians in the community hospital was traditional in instructional format, involving reinforcing in-service and quality-assurance presentations, as well as newsletters. The educational outcomes assessment method was more notable, using retrospective chart reviews with statistically similar patients before and after the educational intervention (15 months of patient charts before, and 6 months after). Patient chart reviews showed statistically significant and clinically meaningful change in VTE prophylaxis performance in practice. Specifically, both “suitable” and “optimal” prophylaxis increased (P = .006 and P < .0001 respectively), with a fourfold increase in the optimally treated percentage of patients associated with pharmacy education of physicians, nurses, and pharmacists.  

These data show that traditional educational initiatives developed by one health care profession for others can be effective in changing performance, especially when guidelines for practice and risk categories are presented in reinforcing text-based and live formats. This intervention brought guideline-adherent care to 93% of patients with risk, up from 49% before the intervention.  

References cited:
Dobesh PP, Stacy ZA. Effect of a clinical pharmacy education program on improvement in the quantity and quality of venous thromboembolism prophylaxis for medically ill patients. J Manag Care Pharm. 2005;11(9):755-62. PMID: 16300419.
Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126:338S-400S. PMID: 15383478.
Jobin S, Kalliainen L, Adebayo L, et al. Venous thromboembolism prophylaxis. Bloomington (MN): Institute for Clinical Systems Improvement (ICSI); 2012. Available at: http://www.guideline.gov/content.aspx?id=39350. Accessed September 7, 2015. 


PubMed:  http://www.ncbi.nlm.nih.gov/pubmed/16300419
Journal Free Full Text: http://amcp.org/data/jmcp/contemporary_755-762.pdf
MeSH *Major* terms: Health Personnel/education; Heparin, Low-Molecular-Weight/therapeutic use; Inservice Training; Thromboembolism/prevention & control; Venous Thrombosis/prevention & control

Mixed-Methods Study Improves Team Communication After Non-Didactic Interprofessional Education on Cardiac Surgical Crisis

It would be hard to imagine a more crucial setting for effective interdisciplinary clinical interactions than the cardiac surgery operating theater. Stevens and colleagues published this 2012 pilot study on interprofessional education to “sharpen performance of experienced cardiac surgical teams in acute crisis management.”

The educational methods support existing effectiveness research for non-didactic education, incorporating both interactive workshops for an entire care unit and computer-based, crisis-case simulations (whose “high-realism” scenarios improved over time). Researchers found that 82% of the 79 participants recommended repetition of case simulations every 6 – 12 months. Workshop participants identified priorities in “encouraging speaking up about critical information and interprofessional information sharing,” particularly early communication of the surgical plan.

The mixed-methods outcomes assessment methodology is also noteworthy because of its appropriateness to this study of human communications and behaviors during a patient crisis: the structured interviews with study participants added context and insights to the quantitative data that could be gathered from periodic surveys. The surveys that were administered before, just after, and 6 months after the educational activities noted that the “concept of working as a team improved between surveys,” as well as “trends for improvement in gaining common understanding of the plan before a procedure and appropriate resolution of disagreements.” The qualitative arm of the study found that interviewees valued the initiative’s “positive effect on their personal behaviors and patient care, including speaking up more readily and communicating more clearly.”

In the continuing medical education field, we often see the Canadians leading educational research, standards, and innovative methods. In fact, looking only at the U. S. National Library of Medicine’s assignment of Medical Subject Headings (MeSH terms) to this indexed article shows the relevance of this study for medical education methods for promoting competence in decision-making, performance-in-practice change, and quality improvement (see “major” MeSH terms listed below, and others on the PubMed page). One hopes to see a follow-up on this pilot study at the Centre Hospitalier Universitaire de Montréal (Quebec, Canada).  

PubMed:  http://www.ncbi.nlm.nih.gov/pubmed/22502966

MeSH *Major* terms: Cardiac Surgical Procedures/education; Clinical Competence; Critical Care/standards; Education, Medical, Continuing/methods; Patient Care Team/organization & administration